IONIS PHARMACEUTICALS INC
Total Trades
283
Buys
2
Sells
161
Largest Trade
N/A
Insiders
21
Institutional Funds
410
Inst. Value
$1M+
Activist Filings
23
Insider Trades
| Insider | Title | Type | Value | Shares | Price | Date |
|---|---|---|---|---|---|---|
| Monia Brett P | CEO | SELL | $1M+ | 204K | $60.32 | Sep 5, 2025 |
| Monia Brett P | CEO | EXERCISE | $1M+ | 204K | $44.32 | Sep 5, 2025 |
| KLEIN JOSEPH III | Director | SELL | $1M+ | 28K | $60.00 | Sep 5, 2025 |
| KLEIN JOSEPH III | Director | EXERCISE | N/A | 28K | — | Sep 5, 2025 |
| KLEIN JOSEPH III | Director | SELL | $1M+ | 28K | $60.00 | Sep 5, 2025 |
| KLEIN JOSEPH III | Director | EXERCISE | N/A | 28K | — | Sep 5, 2025 |
| Geary Richard S | EVP | SELL | $500K+ | 10K | $50.37 | Sep 5, 2025 |
| Devers Shannon L. | EVP | EXERCISE | $100K–$500K | 3K | $36.12 | Sep 5, 2025 |
| Devers Shannon L. | EVP | SELL | $100K–$500K | 3K | $61.02 | Sep 5, 2025 |
| WENDER JOSEPH H | Director | SELL | $1M+ | 28K | $57.58 | Sep 5, 2025 |
| Baroldi Joseph | EVP | EXERCISE | $1M+ | 33K | $31.80 | Sep 5, 2025 |
| Baroldi Joseph | EVP | SELL | $1M+ | 33K | $59.34 | Sep 5, 2025 |
| O'NEIL PATRICK R. | EVP CLO & General … | EXERCISE | $1M+ | 90K | $45.10 | Sep 5, 2025 |
| O'NEIL PATRICK R. | EVP CLO & General … | SELL | $1M+ | 90K | $60.03 | Sep 5, 2025 |
| BENNETT C FRANK | EVP | SELL | $1M+ | 39K | $59.14 | Sep 5, 2025 |
| BENNETT C FRANK | EVP | EXERCISE | $1M+ | 60K | $55.44 | Sep 5, 2025 |
| LOSCALZO JOSEPH | Director | EXERCISE | $100K–$500K | 16K | $24.42 | Sep 5, 2025 |
| LOSCALZO JOSEPH | Director | SELL | $500K+ | 16K | $60.15 | Sep 5, 2025 |
| Schneider Eugene | EVP | EXERCISE | $1M+ | 20K | $53.77 | Sep 5, 2025 |
| Schneider Eugene | EVP | SELL | $1M+ | 20K | $60.81 | Sep 5, 2025 |
| Diaz Allene M. | Director | SELL | $50K–$100K | 1K | $42.53 | Aug 26, 2025 |
| Monia Brett P | CEO | SELL | $100K–$500K | 2K | $45.00 | Aug 1, 2025 |
| Monia Brett P | CEO | EXERCISE | $50K–$100K | 2K | $32.60 | Aug 1, 2025 |
| Monia Brett P | CEO | SELL | $15K–$50K | 1K | $41.74 | Jul 16, 2025 |
| Hayden Michael R | Director | BUY | $100K–$500K | 15K | $31.86 | May 2, 2025 |
| Birchler Brian | EVP | EXERCISE | N/A | 2K | — | Apr 17, 2025 |
| Birchler Brian | EVP | SELL | $15K–$50K | 680 | $28.37 | Apr 17, 2025 |
| Jenne Kyle | EVP | SELL | $50K–$100K | 3K | $28.36 | Apr 17, 2025 |
| Jenne Kyle | EVP | EXERCISE | N/A | 12K | — | Apr 17, 2025 |
| Baroldi Joseph | EVP | EXERCISE | N/A | 11K | — | Apr 17, 2025 |
| Baroldi Joseph | EVP | SELL | $100K–$500K | 4K | $28.40 | Apr 17, 2025 |
| Monia Brett P | CEO | SELL | $1K–$15K | 140 | $32.32 | Mar 13, 2025 |
| O'NEIL PATRICK R. | EVP CLO & General … | SELL | $15K–$50K | 1K | $32.35 | Feb 24, 2025 |
| Swayze Eric | EVP Research | SELL | $100K–$500K | 7K | $32.84 | Jan 18, 2025 |
| Swayze Eric | EVP Research | EXERCISE | N/A | 19K | — | Jan 18, 2025 |
| Schneider Eugene | EVP | EXERCISE | N/A | 17K | — | Jan 18, 2025 |
| Schneider Eugene | EVP | SELL | $100K–$500K | 7K | $32.79 | Jan 18, 2025 |
| O'NEIL PATRICK R. | EVP CLO & General … | SELL | $100K–$500K | 7K | $32.83 | Jan 18, 2025 |
| O'NEIL PATRICK R. | EVP CLO & General … | EXERCISE | N/A | 20K | — | Jan 18, 2025 |
| Monia Brett P | CEO | SELL | $1M+ | 33K | $32.63 | Jan 18, 2025 |
| Monia Brett P | CEO | EXERCISE | N/A | 73K | — | Jan 18, 2025 |
| HOUGEN ELIZABETH L | EVP, Finance & CFO | EXERCISE | N/A | 24K | — | Jan 18, 2025 |
| HOUGEN ELIZABETH L | EVP, Finance & CFO | SELL | $100K–$500K | 9K | $32.81 | Jan 18, 2025 |
| Geary Richard S | EVP | SELL | $100K–$500K | 7K | $32.86 | Jan 18, 2025 |
| Geary Richard S | EVP | EXERCISE | N/A | 19K | — | Jan 18, 2025 |
| Devers Shannon L. | EVP | SELL | $100K–$500K | 4K | $32.78 | Jan 18, 2025 |
| Devers Shannon L. | EVP | EXERCISE | N/A | 12K | — | Jan 18, 2025 |
| Birchler Brian | EVP | SELL | $100K–$500K | 5K | $32.70 | Jan 18, 2025 |
| Birchler Brian | EVP | EXERCISE | N/A | 14K | — | Jan 18, 2025 |
| BENNETT C FRANK | EVP | SELL | $100K–$500K | 7K | $32.90 | Jan 18, 2025 |
Institutional Ownership
13F filings as of Dec 31, 2025 · 410 funds holding
| Fund | Shares | Value | Type |
|---|---|---|---|
| Capital World Investors | 18.0M | $1M+ | SH |
| STATE STREET CORP | 4.0M | $1M+ | SH |
| GEODE CAPITAL MANAGEMENT, LLC | 2.8M | $1M+ | SH |
| Tweedy, Browne Co LLC | 2.5M | $1M+ | SH |
| Deep Track Capital, LP | 1.7M | $1M+ | SH |
| AMERICAN CENTURY COMPANIES INC | 1.6M | $1M+ | SH |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.5M | $1M+ | SH |
| Pictet Asset Management Holding SA | 1.4M | $1M+ | SH |
| Connor, Clark & Lunn Investment Management Ltd. | 1.1M | $1M+ | SH |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1.1M | $1M+ | SH |
| BNP Paribas Asset Management Holding S.A. | 955K | $1M+ | SH |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 865K | $1M+ | SH |
| NOMURA HOLDINGS INC | 849K | $1M+ | SH |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 809K | $1M+ | SH |
| TD ASSET MANAGEMENT INC | 773K | $1M+ | SH |
| GW&K Investment Management, LLC | 742K | $1M+ | SH |
| Candriam S.C.A. | 678K | $1M+ | SH |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 585K | $1M+ | SH |
| EVENTIDE ASSET MANAGEMENT, LLC | 575K | $1M+ | SH |
| GOLDMAN SACHS GROUP INC | 553K | $1M+ | SH |
Activist & 5%+ Owners
SC 13D/13G filings — investors holding 5%+ of outstanding shares
SC 13G/A · Jan 8, 2026
11.1%
18.0M shares
T. Rowe Price Investment Management, Inc.
SC 13G/A · Nov 14, 2025
8.3%
13.2M shares
Wellington Management Group LLP
SC 13G/A · Aug 12, 2025
4.3%
6.9M shares
SC 13G/A · Apr 17, 2025
5.7%
9.1M shares
SC 13G · Feb 13, 2025
7.3%
11.5M shares
T. Rowe Price Investment Management, Inc.
SC 13G/A · Feb 7, 2025
10.0%
15.9M shares
SC 13G/A · Jan 8, 2025
10.4%
16.5M shares
SC 13G/A · Nov 15, 2024
5.0%
7 shares
T. Rowe Price Investment Management, Inc. 85-4328500
SC 13G/A · Nov 14, 2024
9.0%
14.2M shares
Wellington Management Group LLP
SC 13G · Nov 8, 2024
5.8%
9.1M shares
T. Rowe Price Investment Management, Inc. 85-4328500
SC 13G · Feb 14, 2024
9.2%
13.2M shares
The Vanguard Group - 23-1945930
SC 13G/A · Feb 13, 2024
9.9%
14.2M shares
SC 13G/A · Feb 13, 2024
6.0%
8.6M shares
SC 13G/A · Jan 26, 2024
6.3%
9.1M shares
The Vanguard Group - 23-1945930
SC 13G/A · Jun 9, 2023
10.1%
14.4M shares
SC 13G/A · Feb 14, 2023
6.8%
9.6M shares
T. Rowe Price Investment Management, Inc. 85-4328500
SC 13G · Feb 14, 2023
8.2%
11.7M shares
SC 13G/A · Jan 31, 2023
6.5%
9.2M shares
T. ROWE PRICE ASSOCIATES, INC. 52-0556948
SC 13G/A · Aug 10, 2022
3.3%
4.8M shares
T. ROWE PRICE ASSOCIATES, INC. 52-0556948
SC 13G/A · Apr 11, 2022
10.1%
14.4M shares
T. ROWE PRICE ASSOCIATES, INC. 52-0556948
SC 13G/A · Feb 14, 2022
8.8%
12.5M shares
SC 13G/A · Feb 11, 2022
7.2%
10.2M shares
SC 13G · Feb 1, 2022
6.0%
8.5M shares