IONS

IONIS PHARMACEUTICALS INC

Pharmaceutical PreparationsNasdaqLarge accelerated filer

Total Trades

283

Buys

2

Sells

161

Largest Trade

N/A

Insiders

21

Institutional Funds

410

Inst. Value

$1M+

Activist Filings

23

Insider Trades

InsiderTitleTypeValueSharesPriceDate
Birchler BrianEVPSELL$500K+8K$75.11Jan 21, 2026
Birchler BrianEVPEXERCISEN/A20KJan 21, 2026
BENNETT C FRANKEVPSELL$500K+9K$75.15Jan 21, 2026
BENNETT C FRANKEVPEXERCISEN/A21KJan 21, 2026
Baroldi JosephEVPEXERCISEN/A20KJan 21, 2026
Baroldi JosephEVPSELL$500K+8K$75.75Jan 21, 2026
Devers Shannon L.EVPSELL$1M+44K$85.08Jan 9, 2026
Devers Shannon L.EVPEXERCISE$1M+44K$51.25Jan 9, 2026
Swayze EricEVP ResearchSELL$1M+23K$79.12Jan 6, 2026
Swayze EricEVP ResearchEXERCISE$1M+23K$60.89Jan 6, 2026
WENDER JOSEPH HDirectorSELL$1M+28K$80.82Dec 4, 2025
KLEIN JOSEPH IIIDirectorSELL$500K+12K$80.00Nov 28, 2025
KLEIN JOSEPH IIIDirectorEXERCISEN/A12KNov 28, 2025
Devers Shannon L.EVPSELL$1M+17K$80.91Nov 28, 2025
Devers Shannon L.EVPEXERCISE$500K+17K$53.77Nov 28, 2025
HERMAN JOAN EDirectorEXERCISE$1M+44K$57.40Nov 20, 2025
HERMAN JOAN EDirectorSELL$1M+44K$72.13Nov 20, 2025
Birchler BrianEVPSELL$500K+8K$76.17Nov 7, 2025
Geary Richard SEVPSELL$1M+35K$75.69Nov 7, 2025
Geary Richard SEVPEXERCISE$1M+35K$59.05Nov 7, 2025
WENDER JOSEPH HDirectorSELL$1M+28K$74.02Nov 4, 2025
LOSCALZO JOSEPHDirectorSELL$1M+16K$75.10Nov 4, 2025
LOSCALZO JOSEPHDirectorEXERCISE$500K+16K$52.22Nov 4, 2025
Geary Richard SEVPSELL$1M+91K$75.11Nov 4, 2025
Geary Richard SEVPEXERCISE$1M+71K$58.84Nov 4, 2025
WENDER JOSEPH HDirectorSELL$1M+17K$65.50Oct 2, 2025
Swayze EricEVP ResearchEXERCISE$1M+27K$53.77Oct 2, 2025
Swayze EricEVP ResearchSELL$1M+27K$66.16Oct 2, 2025
O'NEIL PATRICK R.EVP CLO & General …SELL$1M+65K$67.69Oct 2, 2025
O'NEIL PATRICK R.EVP CLO & General …EXERCISE$1M+65K$58.97Oct 2, 2025
Baroldi JosephEVPEXERCISE$100K–$500K15K$31.80Oct 2, 2025
Baroldi JosephEVPSELL$1M+15K$68.01Oct 2, 2025
O'NEIL PATRICK R.EVP CLO & General …SELL$1M+25K$64.62Oct 1, 2025
O'NEIL PATRICK R.EVP CLO & General …EXERCISE$1M+25K$56.78Oct 1, 2025
Geary Richard SEVPSELL$1M+58K$65.24Oct 1, 2025
Geary Richard SEVPEXERCISE$1M+58K$53.77Oct 1, 2025
HOUGEN ELIZABETH LEVP, Finance & CFOEXERCISE$1M+50K$53.77Oct 1, 2025
HOUGEN ELIZABETH LEVP, Finance & CFOSELL$1M+50K$65.26Oct 1, 2025
O'NEIL PATRICK R.EVP CLO & General …SELL$100K–$500K2K$64.58Sep 16, 2025
O'NEIL PATRICK R.EVP CLO & General …EXERCISE$50K–$100K2K$56.78Sep 16, 2025
Baroldi JosephEVPEXERCISE$100K–$500K12K$31.80Sep 11, 2025
Baroldi JosephEVPSELL$500K+12K$62.16Sep 11, 2025
O'NEIL PATRICK R.EVP CLO & General …EXERCISE$1M+21K$60.69Sep 11, 2025
O'NEIL PATRICK R.EVP CLO & General …SELL$1M+21K$64.56Sep 11, 2025
Baroldi JosephEVPEXERCISE$1K–$15K250$31.80Sep 9, 2025
Baroldi JosephEVPSELL$15K–$50K250$62.00Sep 9, 2025
BENNETT C FRANKEVPSELL$100K–$500K6K$59.60Sep 9, 2025
Swayze EricEVP ResearchSELL$500K+11K$49.67Sep 5, 2025
WENDER JOSEPH HDirectorSELL$1M+28K$57.58Sep 5, 2025
PARSHALL B LYNNEDirectorSELL$1M+20K$50.91Sep 5, 2025
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Activist & 5%+ Owners

SC 13D/13G filings — investors holding 5%+ of outstanding shares

Capital World Investors

SC 13G/A · Jan 8, 2026

11.1%

18.0M shares

8.3%

13.2M shares

Wellington Management Group LLP

SC 13G/A · Aug 12, 2025

4.3%

6.9M shares

BlackRock, Inc.

SC 13G/A · Apr 17, 2025

5.7%

9.1M shares

Capital World Investors

SC 13G · Feb 13, 2025

7.3%

11.5M shares

10.0%

15.9M shares

The Vanguard Group

SC 13G/A · Jan 8, 2025

10.4%

16.5M shares

BB Biotech AG

SC 13G/A · Nov 15, 2024

5.0%

7 shares

9.0%

14.2M shares

Wellington Management Group LLP

SC 13G · Nov 8, 2024

5.8%

9.1M shares

9.2%

13.2M shares

The Vanguard Group - 23-1945930

SC 13G/A · Feb 13, 2024

9.9%

14.2M shares

BB Biotech AG

SC 13G/A · Feb 13, 2024

6.0%

8.6M shares

BlackRock, Inc.

SC 13G/A · Jan 26, 2024

6.3%

9.1M shares

The Vanguard Group - 23-1945930

SC 13G/A · Jun 9, 2023

10.1%

14.4M shares

BB Biotech AG

SC 13G/A · Feb 14, 2023

6.8%

9.6M shares

8.2%

11.7M shares

BlackRock, Inc.

SC 13G/A · Jan 31, 2023

6.5%

9.2M shares

3.3%

4.8M shares

10.1%

14.4M shares

8.8%

12.5M shares

BB Biotech AG

SC 13G/A · Feb 11, 2022

7.2%

10.2M shares

BlackRock, Inc.

SC 13G · Feb 1, 2022

6.0%

8.5M shares

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