IONS

IONIS PHARMACEUTICALS INC

Pharmaceutical PreparationsNasdaqLarge accelerated filer

Total Trades

283

Buys

2

Sells

161

Largest Trade

N/A

Insiders

21

Institutional Funds

409

Inst. Value

$1M+

Activist Filings

23

Insider Trades

InsiderTitleTypeValueSharesPriceDate
LOSCALZO JOSEPHDirectorEXERCISE$15K–$50K1K$38.06Mar 5, 2026
LOSCALZO JOSEPHDirectorSELL$50K–$100K1K$80.26Mar 5, 2026
KLEIN JOSEPH IIIDirectorSELL$1M+21K$79.51Mar 5, 2026
KLEIN JOSEPH IIIDirectorEXERCISE$500K+16K$40.76Mar 5, 2026
Diaz Allene M.DirectorEXERCISE$1M+40K$39.72Mar 5, 2026
Diaz Allene M.DirectorSELL$1M+55K$79.35Mar 5, 2026
Devers Shannon L.EVPSELL$1M+20K$79.40Mar 5, 2026
Devers Shannon L.EVPEXERCISE$500K+20K$35.97Mar 5, 2026
BENNETT C FRANKEVPEXERCISE$1M+65K$53.73Mar 5, 2026
BENNETT C FRANKEVPSELL$1M+85K$79.23Mar 5, 2026
Baroldi JosephEVPSELL$500K+7K$79.74Mar 5, 2026
Baroldi JosephEVPEXERCISE$50K–$100K2K$44.57Mar 5, 2026
Swayze EricEVP ResearchSELL$1M+16K$81.76Feb 14, 2026
PARSHALL B LYNNEDirectorSELL$100K–$500K5K$82.72Feb 14, 2026
Monia Brett PCEOSELL$1M+29K$85.79Feb 10, 2026
BENNETT C FRANKEVPSELL$1M+85K$82.93Feb 4, 2026
BENNETT C FRANKEVPEXERCISE$1M+65K$53.73Feb 4, 2026
Swayze EricEVP ResearchGRANTN/A12KFeb 3, 2026
Swayze EricEVP ResearchSELL$500K+6K$82.93Feb 3, 2026
Schneider EugeneEVPSELL$500K+6K$83.45Feb 3, 2026
Schneider EugeneEVPGRANTN/A12KFeb 3, 2026
O'NEIL PATRICK R.EVP CLO & General …GRANTN/A12KFeb 3, 2026
O'NEIL PATRICK R.EVP CLO & General …SELL$500K+6K$83.53Feb 3, 2026
Monia Brett PCEOGRANTN/A122KFeb 3, 2026
Monia Brett PCEOSELL$1M+63K$82.72Feb 3, 2026
HOUGEN ELIZABETH LEVP, Finance & CFOGRANTN/A14KFeb 3, 2026
HOUGEN ELIZABETH LEVP, Finance & CFOSELL$500K+7K$83.24Feb 3, 2026
Birchler BrianEVPSELL$500K+6K$83.03Feb 3, 2026
Birchler BrianEVPGRANTN/A12KFeb 3, 2026
BENNETT C FRANKEVPGRANTN/A11KFeb 3, 2026
BENNETT C FRANKEVPSELL$100K–$500K6K$82.95Feb 3, 2026
Baroldi JosephEVPGRANTN/A10KFeb 3, 2026
Baroldi JosephEVPSELL$100K–$500K5K$82.96Feb 3, 2026
Devers Shannon L.EVPSELL$100K–$500K4K$81.34Jan 23, 2026
Swayze EricEVP ResearchSELL$500K+10K$75.34Jan 21, 2026
Swayze EricEVP ResearchEXERCISEN/A21KJan 21, 2026
Schneider EugeneEVPSELL$500K+9K$75.59Jan 21, 2026
Schneider EugeneEVPEXERCISEN/A22KJan 21, 2026
O'NEIL PATRICK R.EVP CLO & General …EXERCISEN/A21KJan 21, 2026
O'NEIL PATRICK R.EVP CLO & General …SELL$500K+9K$75.84Jan 21, 2026
Monia Brett PCEOSELL$1M+44K$74.82Jan 21, 2026
Monia Brett PCEOEXERCISEN/A89KJan 21, 2026
Kordasiewicz Holly B.EVPEXERCISEN/A11KJan 21, 2026
Kordasiewicz Holly B.EVPSELL$100K–$500K4K$75.66Jan 21, 2026
Jenne KyleEVPEXERCISEN/A7KJan 21, 2026
Jenne KyleEVPSELL$100K–$500K2K$75.96Jan 21, 2026
HOUGEN ELIZABETH LEVP, Finance & CFOEXERCISEN/A29KJan 21, 2026
HOUGEN ELIZABETH LEVP, Finance & CFOSELL$500K+13K$75.22Jan 21, 2026
Devers Shannon L.EVPSELL$500K+8K$75.95Jan 21, 2026
Devers Shannon L.EVPEXERCISEN/A17KJan 21, 2026
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Activist & 5%+ Owners

SC 13D/13G filings — investors holding 5%+ of outstanding shares

Capital World Investors

SC 13G/A · Jan 8, 2026

11.1%

18.0M shares

8.3%

13.2M shares

Wellington Management Group LLP

SC 13G/A · Aug 12, 2025

4.3%

6.9M shares

BlackRock, Inc.

SC 13G/A · Apr 17, 2025

5.7%

9.1M shares

Capital World Investors

SC 13G · Feb 13, 2025

7.3%

11.5M shares

10.0%

15.9M shares

The Vanguard Group

SC 13G/A · Jan 8, 2025

10.4%

16.5M shares

BB Biotech AG

SC 13G/A · Nov 15, 2024

5.0%

7 shares

9.0%

14.2M shares

Wellington Management Group LLP

SC 13G · Nov 8, 2024

5.8%

9.1M shares

9.2%

13.2M shares

The Vanguard Group - 23-1945930

SC 13G/A · Feb 13, 2024

9.9%

14.2M shares

BB Biotech AG

SC 13G/A · Feb 13, 2024

6.0%

8.6M shares

BlackRock, Inc.

SC 13G/A · Jan 26, 2024

6.3%

9.1M shares

The Vanguard Group - 23-1945930

SC 13G/A · Jun 9, 2023

10.1%

14.4M shares

BB Biotech AG

SC 13G/A · Feb 14, 2023

6.8%

9.6M shares

8.2%

11.7M shares

BlackRock, Inc.

SC 13G/A · Jan 31, 2023

6.5%

9.2M shares

3.3%

4.8M shares

10.1%

14.4M shares

8.8%

12.5M shares

BB Biotech AG

SC 13G/A · Feb 11, 2022

7.2%

10.2M shares

BlackRock, Inc.

SC 13G · Feb 1, 2022

6.0%

8.5M shares

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