ZYME

Zymeworks Inc.

Pharmaceutical PreparationsNasdaqNon-accelerated filer<br>Smaller reporting company

Total Trades

Buys

Sells

Largest Trade

N/A

Insiders

Institutional Funds

155

Inst. Value

$1M+

Activist Filings

Insider Trades

Insider	Title	Type	Value	Shares	Price	Date
Hollywood Mark	COO	EXERCISE	N/A	18K	—	Jan 13, 2026
Hollywood Mark	COO	SELL	$100K–$500K	6K	$22.67	Jan 13, 2026
Smith Jeffrey T L	EVP & Chief Medica…	EXERCISE	N/A	18K	—	Jan 13, 2026
Smith Jeffrey T L	EVP & Chief Medica…	SELL	$100K–$500K	9K	$22.67	Jan 13, 2026
Moore Paul Andrew	Chief Scientific O…	EXERCISE	N/A	18K	—	Jan 13, 2026
Moore Paul Andrew	Chief Scientific O…	SELL	$100K–$500K	10K	$22.67	Jan 13, 2026
Galbraith Kenneth	Chair & CEO	SELL	$500K+	30K	$22.67	Jan 13, 2026
Galbraith Kenneth	Chair & CEO	EXERCISE	N/A	64K	—	Jan 13, 2026
Smith Jeffrey T L	EVP & Chief Medica…	SELL	$100K–$500K	11K	$25.10	Jan 6, 2026
Smith Jeffrey T L	EVP & Chief Medica…	EXERCISE	N/A	20K	—	Jan 6, 2026
Galbraith Kenneth	Chair & CEO	SELL	$1M+	54K	$25.10	Jan 6, 2026
Galbraith Kenneth	Chair & CEO	EXERCISE	N/A	114K	—	Jan 6, 2026
Moore Paul Andrew	Chief Scientific O…	SELL	$500K+	20K	$25.10	Jan 6, 2026
Moore Paul Andrew	Chief Scientific O…	EXERCISE	N/A	37K	—	Jan 6, 2026
Galbraith Kenneth	Chair & CEO	EXERCISE	N/A	100K	—	Dec 22, 2025
Galbraith Kenneth	Chair & CEO	SELL	$1M+	48K	$27.02	Dec 22, 2025
EcoR1 Capital, LLC	Director	BUY	$500K+	55K	$11.47	May 19, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	129K	$11.32	Apr 18, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	317K	$11.42	Apr 7, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	127K	$11.75	Apr 2, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	97K	$12.61	Mar 27, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	127K	$12.92	Mar 24, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	228K	$12.55	Mar 19, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	1.1M	$12.13	Mar 13, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	141K	$13.88	Jan 21, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	168K	$13.59	Jan 15, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	225K	$13.21	Jan 10, 2025
Moore Paul Andrew	Chief Scientific O…	EXERCISE	N/A	37K	—	Jan 7, 2025
Moore Paul Andrew	Chief Scientific O…	SELL	$100K–$500K	21K	$14.92	Jan 7, 2025
Galbraith Kenneth	Chair & CEO	SELL	$500K+	57K	$14.92	Jan 7, 2025
Galbraith Kenneth	Chair & CEO	EXERCISE	N/A	114K	—	Jan 7, 2025
Smith Jeffrey T L	EVP & Chief Medica…	EXERCISE	N/A	20K	—	Jan 7, 2025
Smith Jeffrey T L	EVP & Chief Medica…	SELL	$100K–$500K	11K	$14.92	Jan 7, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	363K	$14.64	Jan 2, 2025
EcoR1 Capital, LLC	Director	BUY	$1M+	130K	$14.44	Dec 27, 2024
EcoR1 Capital, LLC	10% Owner	BUY	$1M+	3.4M	$8.12	Jun 21, 2023
EcoR1 Capital, LLC	10% Owner	BUY	$1M+	200K	$8.00	Mar 30, 2023
Klompas Neil A	President & COO	EXERCISE	N/A	5K	—	Mar 14, 2023
Klompas Neil A	President & COO	SELL	$15K–$50K	3K	$7.83	Mar 14, 2023
EcoR1 Capital, LLC	10% Owner	BUY	$1M+	308K	$9.70	Jan 23, 2023
EcoR1 Capital, LLC	10% Owner	BUY	$1M+	985K	$9.84	Jan 18, 2023
EcoR1 Capital, LLC	10% Owner	BUY	$1M+	1.0M	$7.67	Jan 12, 2023
Astle Christopher	CFO	EXERCISE	N/A	2K	—	Dec 15, 2022
Astle Christopher	CFO	SELL	$1K–$15K	887	$6.01	Dec 15, 2022
Josephson Neil	Chief Medical Offi…	SELL	$15K–$50K	2K	$8.10	Nov 15, 2022
Josephson Neil	Chief Medical Offi…	EXERCISE	N/A	6K	—	Nov 15, 2022
Josephson Neil	Chief Medical Offi…	EXERCISE	N/A	6K	—	Nov 15, 2022
Josephson Neil	Chief Medical Offi…	SELL	$15K–$50K	2K	$8.10	Nov 15, 2022
Klompas Neil A	COO	SELL	$15K–$50K	3K	$6.88	Mar 12, 2022
Klompas Neil A	COO	EXERCISE	N/A	5K	—	Mar 12, 2022

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Institutional Ownership

13F filings as of Dec 31, 2025 · 155 funds holding

Fund	Shares	Value	Type
Rubric Capital Management LP	5.8M	$1M+	SH
PERCEPTIVE ADVISORS LLC	3.3M	$1M+	SH
Siren, L.L.C.	1.7M	$1M+	SH
Nextech Invest, Ltd.	1.1M	$1M+	SH
DIMENSIONAL FUND ADVISORS LP	1.1M	$1M+	SH
STATE STREET CORP	1.0M	$1M+	SH
Capricorn Fund Managers Ltd	1.0M	$1M+	SH
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	700K	$1M+	SH
Assenagon Asset Management S.A.	647K	$1M+	SH
GEODE CAPITAL MANAGEMENT, LLC	593K	$1M+	SH
Prosight Management, LP	530K	$1M+	SH
Redmile Group, LLC	492K	$1M+	SH
Schonfeld Strategic Advisors LLC	289K	$1M+	SH
PICTON MAHONEY ASSET MANAGEMENT	245K	$1M+	SH
Hillsdale Investment Management Inc.	238K	$1M+	SH
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	221K	$1M+	SH
RENAISSANCE TECHNOLOGIES LLC	221K	$1M+	SH
KENNEDY CAPITAL MANAGEMENT LLC	146K	$1M+	SH
JUPITER ASSET MANAGEMENT LTD	126K	$1M+	SH
HRT FINANCIAL LP	121K	$1M+	SH