Prelude Therapeutics Inc
Total Trades
19
Buys
17
Sells
1
Largest Trade
N/A
Insiders
7
Institutional Funds
33
Inst. Value
$1M+
Activist Filings
17
Insider Trades
| Insider | Title | Type | Value | Shares | Price | Date |
|---|---|---|---|---|---|---|
| Combs Andrew | Chief Chemistry Of… | BUY | $50K–$100K | 100K | $0.69 | Mar 27, 2025 |
| Vaddi Krishna | CEO | BUY | $100K–$500K | 675K | $0.69 | Mar 27, 2025 |
| Vaddi Krishna | CEO | BUY | $1K–$15K | 20K | $0.73 | Mar 24, 2025 |
| Vaddi Krishna | CEO | BUY | $15K–$50K | 39K | $0.75 | Mar 18, 2025 |
| Vaddi Krishna | CEO | BUY | $50K–$100K | 98K | $0.71 | Mar 14, 2025 |
| Vaddi Krishna | CEO | BUY | $1K–$15K | 5K | $1.21 | Jan 3, 2025 |
| Vaddi Krishna | CEO | BUY | $1K–$15K | 10K | $1.20 | Jan 2, 2025 |
| Combs Andrew | Chief Chemistry Of… | BUY | $50K–$100K | 63K | $1.36 | Dec 26, 2024 |
| Vaddi Krishna | CEO | BUY | $1K–$15K | 2K | $5.15 | May 26, 2023 |
| Lim Bryant David | Chief Legal Officer | BUY | $1K–$15K | 2K | $5.39 | May 25, 2023 |
| Chardonnet Laurent | CFO | BUY | $15K–$50K | 5K | $5.50 | May 25, 2023 |
| Vaddi Krishna | CEO | BUY | $50K–$100K | 12K | $5.63 | May 25, 2023 |
| ORBIMED ADVISORS LLC | Director | BUY | $1M+ | 870K | $5.75 | May 24, 2023 |
| Bonita David P | Director | BUY | $1M+ | 870K | $5.75 | May 24, 2023 |
| Huang Jane | President, CMO | SELL | $50K–$100K | 13K | $6.12 | Apr 6, 2023 |
| Huang Jane | President, CMO | EXERCISE | N/A | 38K | — | Apr 6, 2023 |
| Vaddi Krishna | CEO | BUY | $50K–$100K | 19K | $5.13 | Dec 21, 2022 |
| Chardonnet Laurent | CFO | BUY | $15K–$50K | 10K | $4.76 | Dec 12, 2022 |
| Chardonnet Laurent | CFO | BUY | $15K–$50K | 10K | $4.23 | Jun 1, 2022 |
Institutional Ownership
13F filings as of Dec 31, 2025 · 33 funds holding
| Fund | Shares | Value | Type |
|---|---|---|---|
| ORBIMED ADVISORS LLC | 10.9M | $1M+ | SH |
| ACADIAN ASSET MANAGEMENT LLC | 536K | $1M+ | SH |
| MORGAN STANLEY | 276K | $500K+ | SH |
| RENAISSANCE TECHNOLOGIES LLC | 271K | $500K+ | SH |
| GEODE CAPITAL MANAGEMENT, LLC | 232K | $500K+ | SH |
| TD ASSET MANAGEMENT INC | 161K | $100K–$500K | SH |
| VANGUARD GROUP INC | 157K | $100K–$500K | SH |
| STATE STREET CORP | 127K | $100K–$500K | SH |
| SPHERA FUNDS MANAGEMENT LTD. | 123K | $100K–$500K | SH |
| GOLDMAN SACHS GROUP INC | 117K | $100K–$500K | SH |
| JANE STREET GROUP, LLC | 109K | $100K–$500K | SH |
| OMERS ADMINISTRATION Corp | 73K | $100K–$500K | SH |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71K | $100K–$500K | SH |
| Point72 Asset Management, L.P. | 59K | $100K–$500K | SH |
| Focus Partners Wealth | 50K | $100K–$500K | SH |
| Connor, Clark & Lunn Investment Management Ltd. | 46K | $100K–$500K | SH |
| BlackRock, Inc. | 46K | $100K–$500K | SH |
| PRUDENTIAL FINANCIAL INC | 16K | $15K–$50K | SH |
| HSBC HOLDINGS PLC | 14K | $15K–$50K | SH |
| BARCLAYS PLC | 9K | $15K–$50K | SH |
Activist & 5%+ Owners
SC 13D/13G filings — investors holding 5%+ of outstanding shares
SC 13G/A · Feb 13, 2026
13.2%
6.7M shares
SC 13G · Nov 7, 2025
9.9%
4.4M shares
SC 13D/A · Jun 13, 2025
23.5%
10.3M shares
SC 13G/A · May 15, 2025
13.8%
6.4M shares
SC 13G/A · Feb 14, 2025
9.5%
5.5M shares
SC 13G/A · Feb 13, 2025
0.0%
0 shares
SC 13G/A · Feb 13, 2024
0.0%
0 shares
SC 13G/A · Feb 12, 2024
9.8%
4.1M shares
SC 13G/A · Feb 12, 2024
11.1%
4.9M shares
SC 13G/A · Jan 10, 2024
0.6%
265K shares
SC 13D/A · Dec 13, 2023
24.3%
10.2M shares
SC 13G · Nov 13, 2023
7.7%
3.2M shares
SC 13D/A · May 24, 2023
28.6%
15.7M shares
SC 13D/A · May 24, 2023
19.5%
10.2M shares
SC 13G · Feb 13, 2023
5.2%
2.5M shares
SC 13G/A · Feb 10, 2023
10.2%
4.9M shares
SC 13G/A · Feb 10, 2023
11.3%
4.3M shares