Karyopharm Therapeutics Inc.
Total Trades
108
Buys
1
Sells
90
Largest Trade
N/A
Insiders
15
Institutional Funds
42
Inst. Value
$1M+
Activist Filings
41
Insider Trades
| Insider | Title | Type | Value | Shares | Price | Date |
|---|---|---|---|---|---|---|
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $1.27 | Oct 5, 2023 |
| BOHLIN GAREN G | Director | BUY | $15K–$50K | 41K | $1.22 | Sep 12, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $1.33 | Sep 6, 2023 |
| Mason Michael | EVP, CFO & Treasurer | SELL | $1K–$15K | 7K | $1.33 | Sep 5, 2023 |
| Mano Michael | SVP | SELL | $1K–$15K | 4K | $1.33 | Sep 5, 2023 |
| Cheng Sohanya Roshan | EVP & Chief Commer… | SELL | $1K–$15K | 7K | $1.33 | Sep 5, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $1.72 | Aug 8, 2023 |
| Poulton Stuart | EVP | SELL | $1K–$15K | 3K | $1.70 | Aug 1, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $1.72 | Jul 6, 2023 |
| Cheng Sohanya Roshan | EVP & Chief Commer… | SELL | $1K–$15K | 2K | $2.35 | Jun 12, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $2.24 | Jun 7, 2023 |
| Mason Michael | EVP, CFO & Treasurer | SELL | $1K–$15K | 631 | $2.22 | Jun 5, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $3.35 | May 5, 2023 |
| Rangwala Reshma | EVP & Chief Medica… | SELL | $15K–$50K | 7K | $4.05 | Apr 24, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 3K | $3.97 | Apr 5, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $3.16 | Mar 7, 2023 |
| Mitchener Stephen | SVP | GRANT | N/A | 60K | — | Mar 2, 2023 |
| Mitchener Stephen | SVP | SELL | $15K–$50K | 6K | $3.03 | Mar 2, 2023 |
| Mano Michael | SVP | GRANT | N/A | 70K | — | Mar 2, 2023 |
| Mano Michael | SVP | SELL | $15K–$50K | 7K | $3.03 | Mar 2, 2023 |
| Cheng Sohanya Roshan | EVP & Chief Commer… | GRANT | N/A | 100K | — | Mar 2, 2023 |
| Cheng Sohanya Roshan | EVP & Chief Commer… | SELL | $15K–$50K | 11K | $3.03 | Mar 2, 2023 |
| Mason Michael | EVP, CFO & Treasurer | SELL | $15K–$50K | 11K | $3.03 | Mar 2, 2023 |
| Mason Michael | EVP, CFO & Treasurer | GRANT | N/A | 95K | — | Mar 2, 2023 |
| Paulson Richard A. | President and CEO | SELL | $100K–$500K | 33K | $3.03 | Mar 2, 2023 |
| Paulson Richard A. | President and CEO | GRANT | N/A | 252K | — | Mar 2, 2023 |
| Mason Michael | EVP, CFO & Treasurer | SELL | $1K–$15K | 3K | $3.04 | Mar 1, 2023 |
| Poulton Stuart | EVP | SELL | $15K–$50K | 6K | $3.19 | Feb 17, 2023 |
| Mason Michael | EVP, CFO & Treasurer | SELL | $1K–$15K | 4K | $3.40 | Feb 8, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $3.40 | Feb 8, 2023 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 4K | $3.27 | Jan 5, 2023 |
| Paulson Richard A. | President and CEO | SELL | $15K–$50K | 3K | $5.17 | Dec 6, 2022 |
| Paulson Richard A. | President and CEO | SELL | $15K–$50K | 3K | $4.54 | Nov 8, 2022 |
| Paulson Richard A. | President and CEO | SELL | $15K–$50K | 3K | $5.87 | Oct 5, 2022 |
| Paulson Richard A. | President and CEO | SELL | $15K–$50K | 3K | $5.23 | Sep 9, 2022 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 2K | $4.48 | Aug 5, 2022 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 2K | $5.18 | Jul 11, 2022 |
| Cheng Sohanya Roshan | Chief Commercial O… | SELL | $1K–$15K | 2K | $5.21 | Jun 14, 2022 |
| PAKIANATHAN DEEPIKA | Director | SELL | $1M+ | 539K | $6.38 | Jun 10, 2022 |
| Paulson Richard A. | President and CEO | SELL | $1K–$15K | 3K | $5.76 | Jun 8, 2022 |
| Paulson Richard A. | President and CEO | SELL | $100K–$500K | 29K | $6.23 | May 5, 2022 |
| Frenkel Ran | EVP | GRANT | N/A | 68K | — | Mar 2, 2022 |
| Frenkel Ran | EVP | SELL | $15K–$50K | 2K | $10.24 | Mar 2, 2022 |
| Mason Michael | EVP, CFO & Treasurer | GRANT | N/A | 88K | — | Mar 2, 2022 |
| Mason Michael | EVP, CFO & Treasurer | SELL | $15K–$50K | 2K | $10.24 | Mar 2, 2022 |
| Shacham Sharon | Chief Scientific O… | SELL | $100K–$500K | 12K | $10.24 | Mar 2, 2022 |
| Shacham Sharon | Chief Scientific O… | GRANT | N/A | 21K | — | Mar 2, 2022 |
| Kauffman Michael | Director | SELL | $100K–$500K | 12K | $10.24 | Mar 2, 2022 |
| Kauffman Michael | Director | GRANT | N/A | 21K | — | Mar 2, 2022 |
| Shah Jatin | EVP | SELL | $15K–$50K | 1K | $12.12 | Feb 22, 2022 |
Institutional Ownership
13F filings as of Dec 31, 2025 · 42 funds holding
| Fund | Shares | Value | Type |
|---|---|---|---|
| Affinity Asset Advisors, LLC | 890K | $1M+ | SH |
| Ikarian Capital, LLC | 545K | $1M+ | SH |
| Soleus Capital Management, L.P. | 440K | $1M+ | SH |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 310K | $1M+ | SH |
| BRAIDWELL LP | 303K | $1M+ | SH |
| Exome Asset Management LLC | 296K | $1M+ | SH |
| GEODE CAPITAL MANAGEMENT, LLC | 147K | $1M+ | SH |
| Avidity Partners Management LP | 135K | $500K+ | SH |
| GROUP ONE TRADING LLC | 102K | $500K+ | SH |
| C WorldWide Group Holding A/S | 100K | $500K+ | SH |
| Walleye Capital LLC | 96K | $500K+ | SH |
| UBS Group AG | 87K | $500K+ | SH |
| Context Capital Management, LLC | 63K | $100K–$500K | SH |
| RENAISSANCE TECHNOLOGIES LLC | 60K | $100K–$500K | SH |
| STATE STREET CORP | 59K | $100K–$500K | SH |
| Connor, Clark & Lunn Investment Management Ltd. | 57K | $100K–$500K | SH |
| ADAR1 Capital Management, LLC | 50K | $100K–$500K | SH |
| ADAR1 Capital Management, LLC | 50K | $100K–$500K | SH |
| MARSHALL WACE, LLP | 39K | $100K–$500K | SH |
| SIMPLEX TRADING, LLC | 33K | $100K–$500K | SH |
Activist & 5%+ Owners
SC 13D/13G filings — investors holding 5%+ of outstanding shares
Adage Capital Management, L.P.
SC 13G/A · Feb 12, 2026
2.4%
437K shares
Integrated Core Strategies (US) LLC
SC 13G · Feb 10, 2026
5.4%
998K shares
SC 13G/A · Jan 30, 2026
8.6%
1.7M shares
HIGHBRIDGE CAPITAL MANAGEMENT, LLC
SC 13G/A · Nov 14, 2025
4.9%
650K shares
T. Rowe Price Investment Management, Inc.
SC 13G/A · Nov 7, 2025
13.8%
2.3M shares
SC 13G/A · Nov 3, 2025
5.0%
1.0M shares
SC 13G/A · Oct 30, 2025
4.7%
408K shares
SC 13G · Oct 17, 2025
9.5%
1.6M shares
T. Rowe Price Investment Management, Inc.
SC 13G · Aug 14, 2025
8.4%
729K shares
SC 13G · Jul 16, 2025
5.2%
450K shares
SC 13G · Apr 10, 2025
7.8%
664K shares
Adage Capital Management, L.P.
SC 13G · Feb 12, 2025
5.2%
6.6M shares
Avidity Partners Management LP
SC 13G/A · Nov 14, 2024
3.7%
4.7M shares
SC 13G/A · Nov 12, 2024
6.1%
7.7M shares
SC 13G/A · Nov 4, 2024
6.1%
7.7M shares
Highbridge Capital Management, LLC
SC 13G · Oct 25, 2024
7.2%
9.7M shares
SC 13G/A · Jul 8, 2024
3.5%
4.2M shares
SC 13G · May 23, 2024
5.5%
6.9M shares
SC 13G/A · Feb 14, 2024
4.5%
5.1M shares
Avidity Partners Management LP
SC 13G/A · Feb 14, 2024
9.5%
11.2M shares
The Vanguard Group - 23-1945930
SC 13G · Feb 13, 2024
7.6%
8.7M shares
SC 13G/A · Feb 12, 2024
0.0%
0 shares
SC 13G/A · Jan 25, 2024
8.8%
10.1M shares
STATE STREET CORPORATION I.R.S. IDENTIFICATION NO. OF THE ABOVE PERSON 04-2456637
SC 13G/A · Jan 22, 2024
1.8%
0 shares
STATE STREET CORPORATION I.R.S. IDENTIFICATION NO. OF THE ABOVE PERSON 04-2456637
SC 13G/A · Jul 10, 2023
1.9%
0 shares
SC 13G/A · Feb 14, 2023
5.0%
5.7M shares
SC 13G/A · Feb 14, 2023
1.7%
1.9M shares
SC 13G/A · Feb 14, 2023
3.9%
4.4M shares
Avidity Partners Management LP
SC 13G/A · Feb 14, 2023
9.9%
11.4M shares
SC 13G · Feb 10, 2023
7.3%
8.3M shares
STATE STREET CORPORATION I.R.S. IDENTIFICATION NO. OF THE ABOVE PERSON 04-2456637
SC 13G/A · Feb 2, 2023
7.3%
0 shares
SC 13G/A · Jan 26, 2023
10.5%
8.5M shares
SC 13G · Jan 20, 2023
10.5%
8.5M shares
Avidity Partners Management LP
SC 13G · Dec 8, 2022
9.9%
11.4M shares
SC 13G · May 9, 2022
5.1%
4.0M shares
SC 13G/A · Feb 14, 2022
7.2%
5.5M shares
SC 13G/A · Feb 11, 2022
5.2%
4.1M shares
SC 13G/A · Feb 11, 2022
6.6%
5.0M shares
STATE STREET CORPORATION I.R.S. IDENTIFICATION NO. OF THE ABOVE PERSON 04-2456637
SC 13G/A · Feb 11, 2022
7.3%
0 shares
SC 13G · Jan 27, 2022
11.8%
8.9M shares
SC 13G/A · Jan 26, 2022
11.8%
8.9M shares