DNLI

Denali Therapeutics Inc.

Biological Products, (No Diagnostic Substances)NasdaqLarge accelerated filer

Total Trades

112

Buys

Sells

Largest Trade

N/A

Insiders

Institutional Funds

196

Inst. Value

$1M+

Activist Filings

Insider Trades

Insider	Title	Type	Value	Shares	Price	Date
Schuth Alexander O.	COFO and Secretary	SELL	$50K–$100K	3K	$24.18	Aug 14, 2023
Schuth Alexander O.	COFO and Secretary	EXERCISE	$50K–$100K	10K	$5.28	Jul 19, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$500K+	20K	$29.80	Jul 19, 2023
SATO VICKI L	Director	SELL	$15K–$50K	2K	$29.60	Jul 19, 2023
SATO VICKI L	Director	SELL	$15K–$50K	2K	$29.84	Jun 30, 2023
Watts Ryan J.	President and CEO	EXERCISE	$15K–$50K	50K	$0.68	Jun 20, 2023
Watts Ryan J.	President and CEO	SELL	$1M+	50K	$31.40	Jun 20, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$100K–$500K	10K	$28.60	May 17, 2023
Schuth Alexander O.	COFO and Secretary	EXERCISE	$50K–$100K	10K	$5.28	May 17, 2023
Watts Ryan J.	President and CEO	EXERCISE	$15K–$50K	25K	$0.68	Apr 24, 2023
Watts Ryan J.	President and CEO	SELL	$500K+	25K	$25.15	Apr 24, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$100K–$500K	10K	$25.04	Apr 14, 2023
Schuth Alexander O.	COFO and Secretary	EXERCISE	$50K–$100K	10K	$5.28	Apr 14, 2023
Ho Carole	Chief Medical Offi…	SELL	$15K–$50K	1K	$29.40	Feb 17, 2023
Krognes Steve E.	Director	SELL	$50K–$100K	2K	$30.10	Feb 16, 2023
Schuth Alexander O.	COFO and Secretary	EXERCISE	$15K–$50K	25K	$0.68	Feb 16, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$100K–$500K	3K	$30.09	Feb 16, 2023
Watts Ryan J.	President and CEO	EXERCISE	$15K–$50K	25K	$0.68	Feb 16, 2023
Watts Ryan J.	President and CEO	SELL	$1M+	34K	$30.08	Feb 16, 2023
Ho Carole	Chief Medical Offi…	SELL	$100K–$500K	3K	$30.03	Feb 15, 2023
Watts Ryan J.	President and CEO	SELL	$500K+	28K	$29.28	Feb 14, 2023
Watts Ryan J.	President and CEO	EXERCISE	$15K–$50K	25K	$0.68	Feb 14, 2023
Ho Carole	Chief Medical Offi…	SELL	$15K–$50K	2K	$30.88	Feb 10, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$15K–$50K	2K	$30.89	Feb 10, 2023
Krognes Steve E.	Director	SELL	$15K–$50K	1K	$30.88	Feb 10, 2023
Schuth Alexander O.	COFO and Secretary	EXERCISE	$50K–$100K	10K	$5.28	Jan 19, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$100K–$500K	10K	$29.53	Jan 19, 2023
Ho Carole	Chief Medical Offi…	SELL	$15K–$50K	1K	$28.48	Jan 10, 2023
Ho Carole	Chief Medical Offi…	SELL	$100K–$500K	4K	$28.52	Jan 10, 2023
Krognes Steve E.	Director	SELL	$50K–$100K	3K	$28.44	Jan 10, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$50K–$100K	3K	$28.44	Jan 10, 2023
Watts Ryan J.	President and CEO	SELL	$100K–$500K	5K	$28.44	Jan 10, 2023
Ho Carole	Chief Medical Offi…	SELL	$50K–$100K	3K	$28.69	Jan 6, 2023
Ho Carole	Chief Medical Offi…	GRANT	N/A	41K	—	Jan 6, 2023
Schuth Alexander O.	COFO and Secretary	SELL	$50K–$100K	3K	$28.70	Jan 6, 2023
Schuth Alexander O.	COFO and Secretary	GRANT	N/A	41K	—	Jan 6, 2023
Watts Ryan J.	President and CEO	GRANT	N/A	82K	—	Jan 6, 2023
Watts Ryan J.	President and CEO	SELL	$100K–$500K	5K	$28.73	Jan 6, 2023
Tessier-Lavigne Marc	Director	SELL	$500K+	20K	$30.48	Nov 29, 2022
Tessier-Lavigne Marc	Director	SELL	$500K+	20K	$30.27	Nov 3, 2022
Tessier-Lavigne Marc	Director	SELL	$500K+	20K	$30.82	Sep 30, 2022
Tessier-Lavigne Marc	Director	SELL	$500K+	20K	$31.61	Aug 25, 2022
Ho Carole	Chief Medical Offi…	SELL	$50K–$100K	2K	$31.98	Aug 25, 2022
Watts Ryan J.	President and CEO	SELL	$50K–$100K	2K	$33.22	Aug 23, 2022
Krognes Steve E.	Director	SELL	$50K–$100K	2K	$33.22	Aug 23, 2022
Schuth Alexander O.	COFO and Secretary	SELL	$50K–$100K	3K	$33.22	Aug 23, 2022
Ho Carole	Chief Medical Offi…	SELL	$50K–$100K	3K	$33.22	Aug 23, 2022
Tessier-Lavigne Marc	Director	SELL	$500K+	20K	$35.61	Jul 27, 2022
Tessier-Lavigne Marc	Director	SELL	$500K+	20K	$33.83	Mar 25, 2022
Watts Ryan J.	President and CEO	SELL	$100K–$500K	9K	$34.72	Feb 15, 2022

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Institutional Ownership

13F filings as of Dec 31, 2025 · 196 funds holding

Fund	Shares	Value	Type
STATE STREET CORP	6.3M	$1M+	SH
NORGES BANK	5.1M	$1M+	SH
Capital Research Global Investors	3.7M	$1M+	SH
ALLIANCEBERNSTEIN L.P.	3.6M	$1M+	SH
GEODE CAPITAL MANAGEMENT, LLC	3.0M	$1M+	SH
Fisher Asset Management, LLC	2.6M	$1M+	SH
DIMENSIONAL FUND ADVISORS LP	2.2M	$1M+	SH
Aberdeen Group plc	2.0M	$1M+	SH
Point72 Asset Management, L.P.	1.7M	$1M+	SH
BAILLIE GIFFORD & CO	1.5M	$1M+	SH
PRINCIPAL FINANCIAL GROUP INC	1.5M	$1M+	SH
Siren, L.L.C.	1.4M	$1M+	SH
Pictet Asset Management Holding SA	1.3M	$1M+	SH
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1.2M	$1M+	SH
Candriam S.C.A.	1.2M	$1M+	SH
MASTERS CAPITAL MANAGEMENT LLC	1.0M	$1M+	SH
Alyeska Investment Group, L.P.	859K	$1M+	SH
Defilade Capital Management, L.P.	657K	$1M+	SH
Palo Alto Investors LP	641K	$1M+	SH
Cercano Management LLC	625K	$1M+	SH