Amylyx Pharmaceuticals, Inc.
Total Trades
79
Buys
9
Sells
60
Largest Trade
N/A
Insiders
15
Institutional Funds
128
Inst. Value
$1M+
Activist Filings
45
Insider Trades
| Insider | Title | Type | Value | Shares | Price | Date |
|---|---|---|---|---|---|---|
| Klee Justin B. | CEO | SELL | $100K–$500K | 29K | $14.47 | Mar 4, 2026 |
| Cohen Joshua B | CEO | SELL | $100K–$500K | 29K | $14.48 | Mar 4, 2026 |
| Bedrosian Camille L | Chief Medical Offi… | SELL | $50K–$100K | 6K | $14.58 | Mar 4, 2026 |
| FRATES JAMES M | CFO | SELL | $100K–$500K | 8K | $14.52 | Mar 4, 2026 |
| Mazzariello Gina | Chief Legal Officer | SELL | $50K–$100K | 7K | $14.52 | Mar 4, 2026 |
| Mazzariello Gina | Chief Legal Officer | SELL | $15K–$50K | 3K | $14.14 | Feb 25, 2026 |
| FRATES JAMES M | CFO | SELL | $50K–$100K | 4K | $14.65 | Feb 4, 2026 |
| Cohen Joshua B | CEO | SELL | $100K–$500K | 16K | $14.68 | Feb 4, 2026 |
| Mazzariello Gina | Chief Legal Officer | SELL | $50K–$100K | 3K | $14.65 | Feb 4, 2026 |
| Klee Justin B. | CEO | SELL | $100K–$500K | 16K | $14.69 | Feb 4, 2026 |
| Cohen Joshua B | CEO | SELL | $1M+ | 138K | $13.59 | Jan 21, 2026 |
| Cohen Joshua B | CEO | EXERCISE | $1M+ | 200K | $7.57 | Jan 21, 2026 |
| Klee Justin B. | CEO | SELL | $1M+ | 138K | $13.59 | Jan 21, 2026 |
| Klee Justin B. | CEO | EXERCISE | $1M+ | 200K | $7.57 | Jan 21, 2026 |
| FRATES JAMES M | CFO | SELL | $15K–$50K | 3K | $11.11 | Jan 8, 2026 |
| Cohen Joshua B | CEO | SELL | $50K–$100K | 8K | $11.09 | Jan 8, 2026 |
| Klee Justin B. | CEO | SELL | $50K–$100K | 8K | $11.09 | Jan 8, 2026 |
| Firestone Karen | Director | BUY | $100K–$500K | 8K | $12.45 | Dec 24, 2025 |
| Bedrosian Camille L | Chief Medical Offi… | SELL | $50K–$100K | 7K | $14.35 | Dec 3, 2025 |
| Klee Justin B. | CEO | SELL | $100K–$500K | 30K | $14.38 | Oct 2, 2025 |
| Mazzariello Gina | Chief Legal Officer | SELL | $100K–$500K | 9K | $14.58 | Oct 2, 2025 |
| FRATES JAMES M | CFO | SELL | $100K–$500K | 11K | $14.65 | Oct 2, 2025 |
| Cohen Joshua B | CEO | SELL | $100K–$500K | 30K | $14.35 | Oct 2, 2025 |
| Bedrosian Camille L | Chief Medical Offi… | SELL | $100K–$500K | 12K | $14.58 | Oct 2, 2025 |
| FRATES JAMES M | CFO | SELL | $15K–$50K | 11K | $3.47 | Apr 2, 2025 |
| Bedrosian Camille L | Chief Medical Offi… | SELL | $15K–$50K | 12K | $3.47 | Apr 2, 2025 |
| Mazzariello Gina | Chief Legal Officer | SELL | $15K–$50K | 9K | $3.48 | Apr 2, 2025 |
| Cohen Joshua B | CEO | SELL | $50K–$100K | 21K | $3.47 | Apr 2, 2025 |
| Klee Justin B. | CEO | SELL | $50K–$100K | 21K | $3.46 | Apr 2, 2025 |
| Zeiher Bernhardt G | Director | BUY | $15K–$50K | 10K | $3.70 | Mar 24, 2025 |
| Mazzariello Gina | Chief Legal Officer | SELL | $1K–$15K | 4K | $3.15 | Feb 26, 2025 |
| Klee Justin B. | CEO | SELL | $15K–$50K | 7K | $4.04 | Jan 8, 2025 |
| Cohen Joshua B | CEO | SELL | $15K–$50K | 7K | $4.05 | Jan 8, 2025 |
| Bedrosian Camille L | Chief Medical Offi… | SELL | $15K–$50K | 5K | $5.54 | Dec 3, 2024 |
| Klee Justin B. | CEO | SELL | $50K–$100K | 19K | $3.20 | Oct 2, 2024 |
| Cohen Joshua B | CEO | SELL | $50K–$100K | 19K | $3.20 | Oct 2, 2024 |
| Bedrosian Camille L | Chief Medical Offi… | SELL | $15K–$50K | 11K | $3.20 | Oct 2, 2024 |
| Mazzariello Gina | Chief Legal Officer | SELL | $15K–$50K | 9K | $3.20 | Oct 2, 2024 |
| Mazzariello Gina | Chief Legal Officer | SELL | $50K–$100K | 3K | $18.76 | Feb 27, 2024 |
| Mazzariello Gina | Chief Legal Officer | SELL | $100K–$500K | 6K | $20.88 | Aug 17, 2023 |
| FRATES JAMES M | CFO | SELL | $500K+ | 33K | $26.94 | May 19, 2023 |
| FRATES JAMES M | CFO | EXERCISE | $100K–$500K | 33K | $6.88 | May 19, 2023 |
| Yeramian Patrick D | Chief Medical Offi… | EXERCISE | $50K–$100K | 12K | $5.68 | May 17, 2023 |
| Yeramian Patrick D | Chief Medical Offi… | SELL | $100K–$500K | 12K | $29.03 | May 17, 2023 |
| Yeramian Patrick D | Chief Medical Offi… | EXERCISE | $15K–$50K | 50K | $0.99 | Apr 19, 2023 |
| Yeramian Patrick D | Chief Medical Offi… | SELL | $1M+ | 50K | $30.54 | Apr 19, 2023 |
| Morningside Venture Investments Ltd | 10% Owner | SELL | $500K+ | 29K | $30.45 | Mar 31, 2023 |
| Morningside Venture Investments Ltd | 10% Owner | SELL | $1M+ | 161K | $30.42 | Mar 29, 2023 |
| Morningside Venture Investments Ltd | 10% Owner | SELL | $1M+ | 63K | $31.91 | Mar 23, 2023 |
| Klee Justin B. | CEO | SELL | $1M+ | 100K | $31.86 | Mar 21, 2023 |
Institutional Ownership
13F filings as of Dec 31, 2025 · 128 funds holding
| Fund | Shares | Value | Type |
|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 8.3M | $1M+ | SH |
| VANGUARD GROUP INC | 5.1M | $1M+ | SH |
| First Light Asset Management, LLC | 3.4M | $1M+ | SH |
| Almitas Capital LLC | 2.1M | $1M+ | SH |
| STATE STREET CORP | 2.1M | $1M+ | SH |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9M | $1M+ | SH |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.5M | $1M+ | SH |
| Connor, Clark & Lunn Investment Management Ltd. | 1.0M | $1M+ | SH |
| Logos Global Management LP | 950K | $1M+ | SH |
| GOLDMAN SACHS GROUP INC | 895K | $1M+ | SH |
| ADAR1 Capital Management, LLC | 890K | $1M+ | SH |
| ADAR1 Capital Management, LLC | 890K | $1M+ | SH |
| BALYASNY ASSET MANAGEMENT L.P. | 859K | $1M+ | SH |
| Nantahala Capital Management, LLC | 836K | $1M+ | SH |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 713K | $1M+ | SH |
| DIMENSIONAL FUND ADVISORS LP | 686K | $1M+ | SH |
| Sofinnova Investments, Inc. | 527K | $1M+ | SH |
| SILVERARC CAPITAL MANAGEMENT, LLC | 506K | $1M+ | SH |
| Cormorant Asset Management, LP | 400K | $1M+ | SH |
| Patient Square Capital LP | 350K | $1M+ | SH |
Activist & 5%+ Owners
SC 13D/13G filings — investors holding 5%+ of outstanding shares
SC 13G/A · Feb 17, 2026
5.7%
6.2M shares
Adage Capital Management, L.P.
SC 13G/A · Feb 12, 2026
2.5%
2.8M shares
SC 13G/A · Feb 5, 2026
15.0%
16.5M shares
SC 13G · Jan 30, 2026
5.3%
5.8M shares
SC 13G/A · Jan 21, 2026
7.1%
7.8M shares
SC 13G · Nov 17, 2025
5.1%
5.7M shares
Point72 Asset Management, L.P.
SC 13G/A · Nov 14, 2025
2.6%
2.8M shares
SC 13G/A · Nov 14, 2025
8.2%
9.0M shares
Adage Capital Management, L.P.
SC 13G/A · Nov 13, 2025
6.4%
6.8M shares
SC 13G/A · Oct 30, 2025
4.9%
5.3M shares
SC 13G · Oct 7, 2025
10.7%
11.4M shares
Adage Capital Management, L.P.
SC 13G/A · Aug 12, 2025
9.9%
8.8M shares
SC 13G · Jul 29, 2025
5.0%
4.5M shares
SC 13G · Jul 17, 2025
5.5%
4.9M shares
Point72 Asset Management, L.P.
SC 13G · Jun 25, 2025
5.3%
4.7M shares
SC 13G/A · May 15, 2025
8.8%
7.9M shares
Point72 Asset Management, L.P.
SC 13G/A · May 15, 2025
1.2%
1.0M shares
Adage Capital Management, L.P.
SC 13G · May 12, 2025
6.4%
5.7M shares
Panacea Venture Healthcare Fund II, L.P.
SC 13G/A · Feb 14, 2025
2.6%
2.2M shares
SC 13G/A · Feb 14, 2025
7.9%
6.8M shares
Point72 Asset Management, L.P.
SC 13G · Jan 14, 2025
5.6%
4.8M shares
SC 13G/A · Nov 12, 2024
4.5%
3.1M shares
SC 13G · Nov 4, 2024
4.5%
3.1M shares
SC 13G · Oct 25, 2024
6.5%
4.5M shares
SC 13G · Aug 26, 2024
6.8%
4.6M shares
SC 13G/A · Jul 8, 2024
3.9%
2.7M shares
SC 13G · Mar 11, 2024
6.2%
4.2M shares
SC 13G/A · Feb 14, 2024
2.8%
1.9M shares
SC 13G/A · Feb 14, 2024
4.4%
3.0M shares
Point72 Asset Management, L.P.
SC 13G/A · Feb 14, 2024
4.1%
2.8M shares
The Vanguard Group - 23-1945930
SC 13G/A · Feb 13, 2024
7.8%
5.3M shares
SC 13G · Jan 29, 2024
5.9%
4.0M shares
Point72 Asset Management, L.P.
SC 13G · Dec 11, 2023
4.7%
3.2M shares
Morningside Venture Investments Limited
SC 13D/A · Oct 4, 2023
3.4%
2.3M shares
Morningside Venture Investments Limited
SC 13D/A · Aug 17, 2023
6.9%
4.6M shares
SC 13G · Jun 9, 2023
5.4%
3.7M shares
Morningside Venture Investments Limited
SC 13D/A · Apr 3, 2023
12.9%
8.6M shares
SC 13G/A · Feb 14, 2023
9.2%
6.1M shares
SC 13G/A · Feb 14, 2023
7.0%
4.6M shares
Morningside Venture Investments Limited
SC 13D/A · Sep 30, 2022
15.9%
9.3M shares
SC 13G · Sep 21, 2022
2.8%
1.6M shares
SC 13G/A · Sep 10, 2022
9.9%
5.8M shares
SC 13G · Jun 21, 2022
5.1%
3.0M shares
Morningside Venture Investments Limited
SC 13D · Jan 25, 2022
18.9%
10.7M shares
SC 13G · Jan 21, 2022
12.4%
7.2M shares