Vivo Opportunity Fund Holdings, L.P.

Activist investor & 5%+ owner · SC 13D/13G filings

Total Filings

48

Stocks Covered

22

Latest Filing

Feb 20, 2026

Filings

IMUX

Immunic, Inc.

SC 13G · Feb 20, 2026

10.0%

29.1M shares

DBVT

DBV Technologies S.A.

SC 13G/A · Feb 13, 2026

5.7%

15.7M shares

CDTX

Cidara Therapeutics, Inc.

SC 13G/A · Feb 13, 2026

0.0%

0 shares

CAMP

Camp4 Therapeutics Corp

SC 13G/A · Feb 13, 2026

7.4%

3.9M shares

NERV

Minerva Neurosciences, Inc.

SC 13G · Dec 31, 2025

10.0%

8.6M shares

KTTA

Pasithea Therapeutics Corp.

SC 13G · Dec 5, 2025

10.0%

17.6M shares

DRUG

Bright Minds Biosciences Inc.

SC 13G · Nov 14, 2025

6.4%

454K shares

CMPS

COMPASS Pathways plc

SC 13G/A · Nov 14, 2025

3.2%

3.2M shares

CMPX

Compass Therapeutics, Inc.

SC 13G · Nov 14, 2025

5.1%

9.0M shares

SLNO

Soleno Therapeutics, Inc.

SC 13G/A · Nov 14, 2025

4.2%

2.3M shares

UNCY

Unicycive Therapeutics, Inc.

SC 13G/A · Nov 14, 2025

10.0%

6.1M shares

SABS

SAB Biotherapeutics, Inc.

SC 13G · Oct 3, 2025

10.0%

25.9M shares

CAMP

Camp4 Therapeutics Corp

SC 13G · Sep 17, 2025

7.6%

3.6M shares

SLNO

Soleno Therapeutics, Inc.

SC 13G/A · Aug 13, 2025

7.4%

4.0M shares

CDTX

Cidara Therapeutics, Inc.

SC 13G/A · Aug 13, 2025

4.6%

1.2M shares

RGLS

Regulus Therapeutics Inc.

SC 13G/A · May 15, 2025

3.9%

2.7M shares

DCTH

Delcath Systems, Inc.

SC 13G/A · May 15, 2025

2.2%

750K shares

CMPS

COMPASS Pathways plc

SC 13G/A · May 15, 2025

6.6%

6.3M shares

CDTX

Cidara Therapeutics, Inc.

SC 13G/A · May 15, 2025

4.7%

612K shares

UNCY

Unicycive Therapeutics, Inc.

SC 13G/A · May 15, 2025

10.0%

61.0M shares

DBVT

DBV Technologies S.A.

SC 13G · Apr 8, 2025

10.0%

20.4M shares

SLNO

Soleno Therapeutics, Inc.

SC 13G/A · Apr 1, 2025

9.7%

4.5M shares

CDTX

Cidara Therapeutics, Inc.

SC 13G · Dec 9, 2024

5.5%

600K shares

ACRS

Aclaris Therapeutics, Inc.

SC 13G · Nov 21, 2024

7.4%

8.0M shares

DCTH

Delcath Systems, Inc.

SC 13G/A · Nov 15, 2024

5.3%

1.7M shares

UNCY

Unicycive Therapeutics, Inc.

SC 13G/A · Nov 15, 2024

10.0%

61.0M shares

RZLT

Rezolute, Inc.

SC 13G/A · Nov 14, 2024

4.8%

2.8M shares

ADVM

Adverum Biotechnologies, Inc.

SC 13G/A · Nov 14, 2024

1.1%

219K shares

SLNO

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). 1. NAMES OF REPORTING PERSONS Vivo Opportunity Fund Holdings, L.P. 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☒ 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware NUMBER OF SHARES 5. SOLE VOTING POWER 6,291,851 (1) 6. SHARED VOTING POWER 0 7. SOLE DISPOSITIVE POWER 6,291,851 (1) 8. SHARED DISPOSITIVE POWER 0 9. AGGREGATE AMOUNT 6,291,851 (1) 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ☐ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 16.2% (2) 12. TYPE OF REPORTING PERSON PN (1) The shares of common stock, $0.001 par value (the “Common Stock”) of Soleno Therapeutics, Inc. (the “Issuer”) are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. (2) The percent of class was calculated based upon 38,871,594 shares of Common Stock of the Issuer outstanding as of August 2, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (“SEC”) on August 7, 2024. 2 1. NAMES OF REPORTING PERSONS Vivo Opportunity, LLC 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☐ (b) ☒ 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware NUMBER OF SHARES 5. SOLE VOTING POWER 6,291,851 (1) 6. SHARED VOTING POWER 0 7. SOLE DISPOSITIVE POWER 6,291,851 (1) 8. SHARED DISPOSITIVE POWER 0 9. AGGREGATE AMOUNT 6,291,851 (1) 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ☐ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 16.2% (2) 12. TYPE OF REPORTING PERSON OO (1) The shares of Common Stock of the Issuer are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. (2) The percent of class was calculated based upon 38,871,594 shares of Common Stock of the Issuer outstanding as of August 2, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 7, 2024. 3 Explanatory Statement The Reporting Persons initially reported their beneficial ownership of the Issuer on a Schedule 13G filed with the SEC on May 15, 2023 and subsequently reported their beneficial ownership on a Schedule 13D originally filed with the SEC on June 1, 2023, as amended on October 11, 2023 and May 1, 2024 (the “Schedule 13D”). Pursuant to Rule 13d-1(h), the Reporting Persons are eligible to again report their beneficial ownership of shares of Common Stock of the Issuer on a Schedule 13G, and this Schedule 13G shall operate as an amendment to the Schedule 13D. Item 1. Issuer (a)

SC 13G · Sep 5, 2024

16.2%

6.3M shares

TENX

Tenax Therapeutics, Inc.

SC 13G · Aug 14, 2024

10.0%

6.2M shares

SLNO

Soleno Therapeutics, Inc.

SC 13D/A · May 1, 2024

22.5%

7.3M shares

RGLS

Regulus Therapeutics Inc.

SC 13G · Mar 20, 2024

7.7%

5.0M shares

ADVM

Adverum Biotechnologies, Inc.

SC 13G · Feb 14, 2024

7.2%

15.0M shares

CLNN

Clene, Inc.

SC 13G/A · Feb 13, 2024

7.0%

12.5M shares

VSTM

Verastem, Inc.

SC 13G/A · Feb 13, 2024

6.1%

1.5M shares

DCTH

Delcath Systems, Inc.

SC 13G/A · Feb 13, 2024

10.0%

2.7M shares

ATXS

Astria Therapeutics, Inc.

SC 13G/A · Feb 13, 2024

4.5%

2.5M shares

RZLT

Rezolute, Inc.

SC 13G/A · Feb 13, 2024

8.2%

3.2M shares

GRCL

Gracell Biotechnologies Inc.

SC 13G/A · Feb 13, 2024

5.2%

25.9M shares

RZLT

Rezolute, Inc.

SC 13G · Oct 13, 2023

8.8%

3.2M shares

SLNO

Soleno Therapeutics, Inc.

SC 13D/A · Oct 11, 2023

30.5%

8.4M shares

CMPS

COMPASS Pathways plc

SC 13G · Aug 25, 2023

5.1%

3.2M shares

GRCL

Gracell Biotechnologies Inc.

SC 13G · Aug 18, 2023

5.3%

25.9M shares

UNCY

Unicycive Therapeutics, Inc.

SC 13G · Jul 14, 2023

10.0%

60.0M shares

CLNN

Clene, Inc.

SC 13G · Jun 28, 2023

10.0%

17.7M shares

DCTH

Delcath Systems, Inc.

SC 13G · Jun 22, 2023

10.0%

4.9M shares

SLNO

Soleno Therapeutics, Inc.

SC 13D · Jun 1, 2023

50.8%

8.4M shares

SLNO

Soleno Therapeutics, Inc.

SC 13G · May 15, 2023

20.0%

8.4M shares