Spyre Therapeutics, Inc.
Total Trades
10
Buys
0
Sells
9
Largest Trade
$1M+
Insiders
3
Institutional Funds
110
Inst. Value
$1M+
Activist Filings
40
Insider Trades
| Insider | Title | Type | Value | Shares | Price | Date |
|---|---|---|---|---|---|---|
| Burrows Scott L | CFO | SELL | $100K–$500K | 3K | $40.65 | Mar 4, 2026 |
| Burrows Scott L | CFO | EXERCISE | $15K–$50K | 3K | $14.50 | Mar 4, 2026 |
| Turtle Cameron | CEO | SELL | $500K+ | 15K | $42.19 | Mar 4, 2026 |
| Turtle Cameron | CEO | SELL | $100K–$500K | 15K | $32.80 | Feb 5, 2026 |
| Turtle Cameron | CEO | SELL | $100K–$500K | 15K | $30.68 | Jan 7, 2026 |
| Turtle Cameron | CEO | SELL | $100K–$500K | 15K | $29.02 | Dec 4, 2025 |
| Turtle Cameron | CEO | SELL | $1M+ | 45K | $23.33 | Nov 6, 2025 |
| Burrows Scott L | CFO | SELL | $100K–$500K | 18K | $16.26 | Sep 3, 2025 |
| Albers Jeffrey W. | Director | SELL | $100K–$500K | 7K | $36.76 | Nov 8, 2024 |
| Albers Jeffrey W. | Director | SELL | $1K–$15K | 300 | $36.43 | Oct 28, 2024 |
Institutional Ownership
13F filings as of Dec 31, 2025 · 110 funds holding
| Fund | Shares | Value | Type |
|---|---|---|---|
| Fairmount Funds Management LLC | 4.0M | $1M+ | SH |
| VR Adviser, LLC | 3.7M | $1M+ | SH |
| Capital International Investors | 3.5M | $1M+ | SH |
| PERCEPTIVE ADVISORS LLC | 3.1M | $1M+ | SH |
| STATE STREET CORP | 2.3M | $1M+ | SH |
| TANG CAPITAL MANAGEMENT LLC | 1.9M | $1M+ | SH |
| BRAIDWELL LP | 1.6M | $1M+ | SH |
| RA CAPITAL MANAGEMENT, L.P. | 1.6M | $1M+ | SH |
| Remedium Capital Partners, LLC | 1.5M | $1M+ | SH |
| GEODE CAPITAL MANAGEMENT, LLC | 1.4M | $1M+ | SH |
| Affinity Asset Advisors, LLC | 1.4M | $1M+ | SH |
| Pictet Asset Management Holding SA | 914K | $1M+ | SH |
| Siren, L.L.C. | 819K | $1M+ | SH |
| UBS Group AG | 676K | $1M+ | SH |
| Point72 Asset Management, L.P. | 662K | $1M+ | SH |
| EMERALD ADVISERS, LLC | 636K | $1M+ | SH |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 575K | $1M+ | SH |
| Candriam S.C.A. | 426K | $1M+ | SH |
| EMERALD MUTUAL FUND ADVISERS TRUST | 412K | $1M+ | SH |
| Capital World Investors | 200K | $1M+ | SH |
Activist & 5%+ Owners
SC 13D/13G filings — investors holding 5%+ of outstanding shares
SC 13G/A · Feb 17, 2026
2.4%
1.9M shares
Fairmount Funds Management LLC
SC 13D/A · Oct 17, 2025
9.0%
7.3M shares
SC 13G · Jul 29, 2025
5.1%
3.1M shares
SC 13G/A · Jul 16, 2025
6.6%
4.0M shares
SC 13G · May 1, 2025
5.3%
3.2M shares
Venrock Healthcare Capital Partners III, L.P.
SC 13G/A · Feb 14, 2025
4.6%
2.7M shares
SC 13G/A · Feb 14, 2025
4.4%
2.6M shares
SC 13G/A · Feb 14, 2025
6.2%
3.6M shares
Venrock Healthcare Capital Partners III, L.P.
SC 13G/A · Nov 14, 2024
5.3%
2.7M shares
SC 13G/A · Nov 14, 2024
5.7%
2.9M shares
SC 13G/A · Nov 14, 2024
3.9%
2.0M shares
SC 13G/A · Nov 14, 2024
1.7%
885K shares
SC 13G/A · Nov 12, 2024
15.0%
7.6M shares
SC 13G · Nov 8, 2024
5.2%
2.7M shares
SC 13G · Oct 23, 2024
7.0%
3.6M shares
SC 13G · Oct 22, 2024
5.2%
2.7M shares
SC 13G/A · Jun 10, 2024
13.0%
6.6M shares
Fairmount Funds Management LLC
SC 13D/A · Apr 25, 2024
10.0%
4.0M shares
SC 13G/A · Apr 23, 2024
5.1%
1.8M shares
SC 13G/A · Mar 11, 2024
18.2%
6.6M shares
Venrock Healthcare Capital Partners III, L.P.
SC 13G/A · Feb 15, 2024
10.0%
3.7M shares
Nantahala Capital Management, LLC
SC 13G/A · Feb 14, 2024
0.0%
0 shares
SC 13G/A · Feb 14, 2024
2.5%
887K shares
SC 13G/A · Feb 14, 2024
7.2%
2.6M shares
SC 13G/A · Feb 14, 2024
0.0%
0 shares
SC 13G/A · Feb 14, 2024
5.4%
1.9M shares
SC 13G/A · Feb 14, 2024
0.4%
150K shares
Rock Springs Capital Management LP
SC 13G/A · Feb 14, 2024
0.0%
0 shares
SC 13G · Feb 14, 2024
5.9%
2.1M shares
SC 13G · Feb 14, 2024
6.2%
2.2M shares
BCLS II Equity Opportunities, LP 2
SC 13G/A · Feb 13, 2024
12.0%
0 shares
Suvretta Capital Management, LLC
SC 13G/A · Feb 13, 2024
1.0%
412K shares
Affinity Healthcare Fund, LP (EIN 82-1629802)
SC 13G/A · Feb 13, 2024
1.8%
653K shares
SC 13G/A · Feb 13, 2024
1.1%
500K shares
SC 13G/A · Feb 12, 2024
13.1%
6.2M shares
Fairmount Funds Management LLC
SC 13D/A · Dec 29, 2023
1.1%
378K shares
SC 13G · Dec 13, 2023
7.2%
2.6M shares
Fairmount Funds Management LLC
SC 13D/A · Dec 11, 2023
10.6%
3.8M shares
SC 13G · Dec 1, 2023
6.1%
1.8M shares
Fairmount Funds Management LLC
SC 13D/A · Nov 29, 2023
12.7%
3.8M shares