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OPK

OPKO HEALTH, INC.

Pharmaceutical PreparationsNasdaqLarge accelerated filer

Total Trades

78

Buys

77

Sells

0

Largest Trade

$1M+

Insiders

7

Institutional Funds

175

Inst. Value

$1M+

Activist Filings

20

Insider Trades

InsiderTitleTypeValueSharesPriceDate
FROST PHILLIP MD ET ALCEO & ChairmanBUY$500K+580K$1.33Nov 21, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$500K+580K$1.33Nov 20, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$500K+580K$1.31Nov 19, 2025
FROST PHILLIP MD ET ALCEO & ChairmanGRANT$50K–$100K47K$1.26Nov 18, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$500K+533K$1.27Nov 18, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K150K$1.42Oct 31, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K125K$1.36Apr 10, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K125K$1.48Apr 8, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.65Apr 1, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K150K$1.70Mar 28, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K200K$1.74Mar 17, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K67K$1.71Mar 1, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$50K–$100K48K$1.47Jan 28, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K150K$1.47Jan 17, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$500K+500K$1.48Jan 15, 2025
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K199K$1.53Nov 29, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.59Nov 22, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.62Nov 14, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K280K$1.50Nov 8, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.27May 24, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K500K$0.99Feb 28, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$500K+1.0M$0.99Feb 21, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$1M+1.5M$0.98Feb 7, 2024
KRASNO RICHARD MDirectorBUY$15K–$50K30K$0.99Jan 29, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K500K$0.98Jan 19, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K400K$0.97Jan 18, 2024
HSIAO JANE PH DVice Chairman & CTOBUY$100K–$500K150K$0.95Jan 17, 2024
FROST PHILLIP MD ET ALCEO & ChairmanBUY$500K+1.0M$0.95Jan 16, 2024
PFENNIGER RICHARD C JRDirectorBUY$15K–$50K25K$1.30Nov 14, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$1M+1.0M$1.27Nov 13, 2023
HSIAO JANE PH DVice Chairman & CTOBUY$100K–$500K100K$1.27Nov 13, 2023
Rubin Steven DExecutive VP-Admin…BUY$1K–$15K10K$1.30Nov 13, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.76Aug 18, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K75K$1.75Aug 15, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.82Aug 10, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$1M+650K$1.84Aug 8, 2023
Nabel Gary J.Chief Innovation O…BUY$500K+460K$1.83May 8, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K200K$1.32Mar 23, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$1M+1.0M$1.18Mar 9, 2023
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K300K$1.49Nov 23, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K200K$1.60Nov 10, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.82Oct 28, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.72Oct 20, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.72Oct 17, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.79Oct 14, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K100K$1.73Oct 13, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$100K–$500K75K$1.77Oct 11, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$50K–$100K50K$1.80Sep 27, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$50K–$100K50K$1.85Sep 26, 2022
FROST PHILLIP MD ET ALCEO & ChairmanBUY$50K–$100K50K$1.90Sep 23, 2022
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Institutional Ownership

13F filings as of Dec 31, 2025 · 175 funds holding

FundShares
Rubric Capital Management LP47.8M
VANGUARD GROUP INC29.3M
GEODE CAPITAL MANAGEMENT, LLC9.7M
STATE STREET CORP9.0M
Whitefort Capital Management, LP4.3M
CHARLES SCHWAB INVESTMENT MANAGEMENT INC3.7M
AWM Investment Company, Inc.2.1M
AQR CAPITAL MANAGEMENT LLC2.0M
JANE STREET GROUP, LLC1.4M
WASHINGTON GROWTH STRATEGIES LLC1.4M
Y.D. More Investments Ltd1.3M
PFG Investments, LLC1.3M
DIMENSIONAL FUND ADVISORS LP968K
Tejara Capital Ltd878K
Swiss National Bank846K
UBS Group AG710K
HRT FINANCIAL LP675K
BARCLAYS PLC663K
Assenagon Asset Management S.A.652K
COMMONWEALTH EQUITY SERVICES, LLC641K

Activist & 5%+ Owners

SC 13D/13G filings — investors holding 5%+ of outstanding shares

FROST PHILLIP MD ET AL

SC 13D/A · Oct 1, 2025

32.8%

252.9M shares

Rubric Capital Management LP

SC 13G/A · Jul 9, 2025

6.0%

47.8M shares

FROST PHILLIP MD ET AL

SC 13D/A · Apr 3, 2025

31.7%

252.4M shares

HSIAO JANE PH D

SC 13D/A · Apr 3, 2025

4.5%

35.7M shares

Frost Gamma Investments Trust

SC 13D/A · Nov 15, 2024

31.5%

211.6M shares

Rubric Capital Management LP

SC 13G · Nov 13, 2024

7.0%

48.7M shares

The Vanguard Group

SC 13G/A · Nov 12, 2024

4.2%

29.2M shares

The Vanguard Group

SC 13G/A · Nov 4, 2024

4.2%

29.2M shares

Frost Gamma Investments Trust

SC 13D/A · Aug 29, 2024

30.5%

211.2M shares

The Vanguard Group - 23-1945930

SC 13G/A · Feb 13, 2024

5.1%

39.8M shares

Hsu Gamma Investments, LP

SC 13D/A · Jan 24, 2024

0.7%

5.1M shares

Frost Gamma Investments Trust

SC 13D/A · Jan 24, 2024

29.5%

205.9M shares

Frost Gamma Investments Trust

SC 13D/A · Jan 22, 2024

28.7%

205.9M shares

Frost Gamma Investments Trust

SC 13D/A · Feb 21, 2023

27.2%

213.9M shares

Frost Gamma Investments Trust

SC 13D/A · Aug 19, 2022

26.0%

202.2M shares

Hsu Gamma Investments, LP

SC 13D/A · Aug 19, 2022

0.7%

5.1M shares

Elias A. Zerhouni, M.D.

SC 13D · Jun 29, 2022

2.9%

19.9M shares

Gary J. Nabel, M.D., Ph.D.

SC 13D · Jun 29, 2022

2.9%

20.0M shares

BlackRock, Inc.

SC 13G/A · Mar 9, 2022

5.0%

34.0M shares

BlackRock, Inc.

SC 13G/A · Feb 1, 2022

5.0%

34.4M shares

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