PRAX

Praxis Precision Medicines, Inc.

Pharmaceutical PreparationsNasdaqLarge accelerated filer

Total Trades

18

Buys

10

Sells

4

Largest Trade

$1M+

Insiders

6

Institutional Funds

196

Inst. Value

$1M+

Activist Filings

50

Insider Trades

InsiderTitleTypeValueSharesPriceDate
Nemiroff AlexGeneral Counsel an…EXERCISE$1M+25K$73.76Nov 22, 2025
Nemiroff AlexGeneral Counsel an…SELL$1M+25K$193.09Nov 22, 2025
Mastrocola LaurenPrincipal Accounti…SELL$1M+14K$192.08Nov 22, 2025
Mastrocola LaurenPrincipal Accounti…EXERCISE$500K+14K$61.12Nov 22, 2025
Nemiroff AlexGeneral Counsel an…SELL$500K+8K$80.20Nov 16, 2024
Nemiroff AlexGeneral Counsel an…EXERCISE$100K–$500K8K$56.94Nov 16, 2024
Mastrocola LaurenPrincipal Accounti…EXERCISE$100K–$500K4K$56.94Nov 16, 2024
Mastrocola LaurenPrincipal Accounti…SELL$100K–$500K5K$81.78Nov 16, 2024
DeSimone JillDirectorBUY$15K–$50K15K$1.75Oct 10, 2023
Souza MarcioCEOBUY$1K–$15K10K$1.06Jun 27, 2023
Souza MarcioCEOBUY$50K–$100K70K$0.86Mar 27, 2023
MITCHELL DEAN JDirectorBUY$15K–$50K50K$0.84Mar 27, 2023
Kelly Timothy EdwinCFOBUY$1K–$15K8K$0.87Mar 27, 2023
Mastrocola LaurenPrincipal Accounti…BUY$1K–$15K3K$1.93Jun 21, 2022
Nemiroff AlexGeneral Counsel an…BUY$1K–$15K8K$1.63Jun 14, 2022
Kelly Timothy EdwinCFOBUY$15K–$50K10K$1.76Jun 13, 2022
Souza MarcioCEOBUY$15K–$50K27K$1.85Jun 9, 2022
MITCHELL DEAN JDirectorBUY$15K–$50K25K$1.81Jun 9, 2022
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Activist & 5%+ Owners

SC 13D/13G filings — investors holding 5%+ of outstanding shares

ORBIS INVESTMENT MANAGEMENT LTD

SC 13G · Feb 17, 2026

5.0%

1.3M shares

Adage Capital Management, L.P.

SC 13G/A · Feb 12, 2026

3.8%

965K shares

FMR LLC

SC 13G · Feb 5, 2026

5.4%

1.4M shares

Point72 Asset Management, L.P.

SC 13G/A · Nov 14, 2025

9.3%

2.0M shares

Cormorant Asset Management, LP

SC 13G/A · Nov 14, 2025

4.0%

1.0M shares

T. Rowe Price Associates, Inc.

SC 13G/A · Nov 14, 2025

4.8%

1.0M shares

JANUS HENDERSON GROUP PLC

SC 13G/A · Nov 14, 2025

12.3%

2.8M shares

Morgan Stanley

SC 13G/A · Nov 7, 2025

2.9%

618K shares

Adage Capital Management, L.P.

SC 13G/A · Nov 3, 2025

5.3%

1.3M shares

Adage Capital Management, L.P.

SC 13G/A · Sep 2, 2025

11.3%

2.4M shares

Point72 Asset Management, L.P.

SC 13G/A · Aug 14, 2025

7.0%

1.5M shares

Cormorant Asset Management, LP

SC 13G/A · Aug 14, 2025

7.7%

1.6M shares

JANUS HENDERSON GROUP PLC

SC 13G/A · Aug 14, 2025

12.4%

2.5M shares

Adage Capital Management, L.P.

SC 13G/A · Aug 12, 2025

9.7%

2.0M shares

Soleus Capital Master Fund, L.P.

SC 13G/A · Aug 5, 2025

4.6%

967K shares

Perceptive Advisors LLC

SC 13G · Jul 22, 2025

6.7%

1.4M shares

JANUS HENDERSON GROUP PLC

SC 13G/A · Jun 6, 2025

11.3%

2.3M shares

4.9%

1.0M shares

Point72 Asset Management, L.P.

SC 13G/A · May 15, 2025

5.5%

1.1M shares

Perceptive Advisors LLC

SC 13G/A · May 15, 2025

4.8%

981K shares

Cormorant Asset Management, LP

SC 13G/A · May 15, 2025

8.6%

1.7M shares

JANUS HENDERSON GROUP PLC

SC 13G · May 14, 2025

7.6%

1.5M shares

Capital Research Global Investors

SC 13G/A · May 13, 2025

4.2%

854K shares

Adage Capital Management, L.P.

SC 13G · May 12, 2025

8.6%

1.7M shares

Soleus Capital Master Fund, L.P.

SC 13G · Mar 19, 2025

5.0%

1.0M shares

6.1%

1.2M shares

Perceptive Advisors LLC

SC 13G/A · Feb 14, 2025

9.5%

1.8M shares

Point72 Asset Management, L.P.

SC 13G/A · Feb 14, 2025

5.9%

1.2M shares

Cormorant Asset Management, LP

SC 13G/A · Feb 14, 2025

9.1%

1.7M shares

Morgan Stanley

SC 13G · Feb 5, 2025

6.2%

1.2M shares

Point72 Asset Management, L.P.

SC 13G/A · Nov 15, 2024

9.3%

1.7M shares

5.0%

906K shares

RA Capital Management, L.P.

SC 13G/A · Nov 14, 2024

4.3%

762K shares

Cormorant Asset Management, LP

SC 13G/A · Nov 14, 2024

4.7%

870K shares

6.3%

1.1M shares

Verition Fund Management LLC

SC 13G/A · Nov 14, 2024

1.8%

314K shares

The Vanguard Group

SC 13G/A · Nov 12, 2024

5.8%

1.0M shares

5.6%

997K shares

Adage Capital Management, L.P.

SC 13G/A · Nov 12, 2024

4.8%

854K shares

BlackRock, Inc.

SC 13G · Nov 8, 2024

7.3%

1.3M shares

The Vanguard Group

SC 13G/A · Nov 4, 2024

5.8%

1.0M shares

BlackRock, Inc.

SC 13G · Oct 22, 2024

7.3%

1.3M shares

Perceptive Advisors LLC

SC 13G · Sep 23, 2024

6.3%

1.1M shares

RA Capital Management, L.P.

SC 13G · Jul 2, 2024

7.2%

1.2M shares

8.9%

824K shares

Point72 Asset Management, L.P.

SC 13G/A · Feb 14, 2024

7.9%

692K shares

PFM Health Sciences, LP

SC 13G/A · Feb 14, 2024

0.5%

6 shares

7.4%

633K shares

Eventide Asset Management, LLC

SC 13G/A · Feb 14, 2024

0.0%

0 shares

0.0%

0 shares

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