APLT

Applied Therapeutics, Inc.

Pharmaceutical PreparationsNasdaqNon-accelerated filer<br>Smaller reporting company

Total Trades

27

Buys

5

Sells

19

Largest Trade

N/A

Insiders

7

Institutional Funds

36

Inst. Value

$1M+

Activist Filings

50

Insider Trades

InsiderTitleTypeValueSharesPriceDate
Kanter Stacy J.DirectorSELL$1K–$15K43K$0.11Dec 18, 2025
Funtleyder Leslie D.CFOSELL$50K–$100K14K$5.83Aug 23, 2024
Perfetti RiccardoChief Medical Offi…SELL$100K–$500K23K$5.83Aug 23, 2024
Shendelman ShoshanaPresident and CEOSELL$100K–$500K62K$4.32Jun 10, 2024
Perfetti RiccardoChief Medical Offi…SELL$50K–$100K22K$4.32Jun 10, 2024
Funtleyder Leslie D.CFOSELL$50K–$100K17K$4.32Jun 10, 2024
ALEXANDRIA REAL ESTATE EQUITIES, INC.10% OwnerSELL$1M+300K$4.22Jun 6, 2024
Shendelman ShoshanaPresident and CEOSELL$1K–$15K4K$1.97Dec 2, 2023
Perfetti RiccardoChief Medical Offi…SELL$1K–$15K2K$1.97Dec 2, 2023
Hansard AdamChief Commercial O…SELL$1K–$15K965$1.97Dec 2, 2023
ALEXANDRIA REAL ESTATE EQUITIES, INC.10% OwnerSELL$500K+247K$2.31Nov 6, 2023
ALEXANDRIA REAL ESTATE EQUITIES, INC.10% OwnerSELL$500K+328K$2.38Nov 2, 2023
Shendelman ShoshanaPresident and CEOSELL$100K–$500K116K$2.70Sep 30, 2023
Perfetti RiccardoChief Medical Offi…SELL$15K–$50K11K$2.70Sep 30, 2023
Hansard AdamChief Commercial O…SELL$15K–$50K10K$2.70Sep 30, 2023
Shendelman ShoshanaPresident and CEOGRANTN/A2.0MJan 13, 2023
Shendelman ShoshanaPresident and CEOSELL$1K–$15K16K$0.91Jan 13, 2023
Perfetti RiccardoChief Medical Offi…SELL$1K–$15K6K$0.91Jan 13, 2023
Perfetti RiccardoChief Medical Offi…GRANTN/A550KJan 13, 2023
Hansard AdamChief Commercial O…SELL$1K–$15K4K$0.91Jan 13, 2023
Hansard AdamChief Commercial O…GRANTN/A300KJan 13, 2023
Shendelman ShoshanaPresident and CEOBUY$15K–$50K50K$0.65Oct 14, 2022
Shendelman ShoshanaPresident and CEOBUY$15K–$50K73K$0.56Oct 13, 2022
Shendelman ShoshanaPresident and CEOBUY$15K–$50K38K$0.52Oct 13, 2022
ALEXANDRIA REAL ESTATE EQUITIES, INC.10% OwnerBUY$1M+3.5M$1.00Jun 29, 2022
Mahadevan ChidsSee RemarksSELL$1K–$15K905$1.65May 19, 2022
Perfetti RiccardoChief Medical Offi…BUY$100K–$500K65K$1.95Mar 24, 2022
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Institutional Ownership

13F filings as of Dec 31, 2025 · 36 funds holding

FundShares
DELTEC ASSET MANAGEMENT LLC3.8M
Pathstone Holdings, LLC2.6M
RENAISSANCE TECHNOLOGIES LLC2.7M
JANE STREET GROUP, LLC1.7M
GEODE CAPITAL MANAGEMENT, LLC1.2M
DEUTSCHE BANK AG\622K
STATE STREET CORP558K
Virtu Financial LLC496K
MARSHALL WACE, LLP337K
Hennion & Walsh Asset Management, Inc.327K
EQUITEC PROPRIETARY MARKETS, LLC301K
Bank of New York Mellon Corp254K
GTS SECURITIES LLC200K
CreativeOne Wealth, LLC170K
CITIGROUP INC163K
GOLDMAN SACHS GROUP INC134K
Roble, Belko & Company, Inc66K
UBS Group AG70K
TUDOR INVESTMENT CORP ET AL57K
SPHERA FUNDS MANAGEMENT LTD.50K

Activist & 5%+ Owners

SC 13D/13G filings — investors holding 5%+ of outstanding shares

Propel Bio Management, LLC

SC 13G/A · Dec 31, 2025

4.2%

6.0M shares

4.3%

6.5M shares

14.9%

21.4M shares

13.2%

18.7M shares

The Vanguard Group

SC 13G/A · Jul 29, 2025

3.3%

4.7M shares

BlackRock, Inc.

SC 13G/A · Jul 16, 2025

3.7%

5.2M shares

4.1%

5.6M shares

Schonfeld Strategic Advisors LLC

SC 13G/A · May 15, 2025

3.3%

4.7M shares

11.0%

15.6M shares

8.9%

10.4M shares

The Vanguard Group

SC 13G · Apr 30, 2025

5.1%

5.9M shares

9.9%

11.8M shares

Alyeska Investment Group, L.P.

SC 13G · Feb 14, 2025

5.8%

6.7M shares

Schonfeld Strategic Advisors LLC

SC 13G · Feb 14, 2025

7.5%

8.8M shares

Perceptive Advisors LLC

SC 13G/A · Feb 14, 2025

2.4%

2.9M shares

Vestal Point Capital, LP

SC 13G · Feb 14, 2025

9.9%

11.5M shares

JANUS HENDERSON GROUP PLC

SC 13G/A · Feb 14, 2025

0.0%

36K shares

Morgan Stanley

SC 13G/A · Feb 7, 2025

2.5%

2.9M shares

BlackRock, Inc.

SC 13G/A · Feb 5, 2025

8.0%

9.3M shares

10.1%

5.0M shares

Morgan Stanley

SC 13G/A · Feb 3, 2025

7.6%

8.8M shares

Franklin Resources, Inc.

SC 13G/A · Jan 27, 2025

1.7%

2.0M shares

JANUS HENDERSON GROUP PLC

SC 13G/A · Dec 6, 2024

10.4%

12.1M shares

10.0%

11.7M shares

Perceptive Advisors LLC

SC 13G/A · Nov 14, 2024

8.5%

10.0M shares

Alyeska Investment Group, L.P.

SC 13G/A · Nov 14, 2024

4.2%

5.0M shares

9.2%

10.5M shares

Vestal Point Capital, LP

SC 13G/A · Nov 14, 2024

1.0%

1.1M shares

10.3%

12.6M shares

BlackRock, Inc.

SC 13G · Nov 8, 2024

6.0%

6.9M shares

8.6%

9.9M shares

Franklin Resources, Inc.

SC 13G/A · Oct 31, 2024

5.9%

6.8M shares

BlackRock, Inc.

SC 13G · Oct 24, 2024

6.0%

6.9M shares

Shoshana Shendelman

SC 13D/A · Aug 14, 2024

6.6%

7.8M shares

6.1%

6.4M shares

Shoshana Shendelman

SC 13D/A · Mar 5, 2024

8.2%

8.6M shares

Propel Bio Management LLC

SC 13G/A · Feb 22, 2024

10.5%

8.1M shares

10.0%

7.9M shares

OrbiMed Advisors LLC

SC 13G/A · Feb 14, 2024

0.0%

0 shares

Perceptive Advisors LLC

SC 13G/A · Feb 14, 2024

5.9%

4.6M shares

15.4%

12.9M shares

Armistice Capital, LLC

SC 13G/A · Feb 14, 2024

0.0%

0 shares

Alyeska Investment Group, L.P.

SC 13G/A · Feb 14, 2024

10.0%

7.7M shares

Vestal Point Capital, LP

SC 13G · Feb 13, 2024

5.4%

4.2M shares

Franklin Resources, Inc.

SC 13G/A · Dec 11, 2023

10.2%

7.9M shares

Perceptive Advisors LLC

SC 13G · Dec 6, 2023

5.9%

4.6M shares

Shoshana Shendelman

SC 13D/A · Nov 13, 2023

10.1%

8.1M shares

Franklin Resources, Inc.

SC 13G/A · May 10, 2023

16.5%

7.9M shares

10.0%

5.8M shares

Propel Bio Management, LLC

SC 13G · May 2, 2023

9.9%

4.8M shares

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